SB-357,134

SB-357,134
(IUPAC) ime
	N-(2,5-Dibromo-3-fluorofenil)-4-metoksi-3-(1-piperazinil)benzensulfonamid
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem	6918553
ChEMBL	CHEMBL329383
Hemijski podaci
Formula	C17H18Br2FN3O3S
Mol. masa	523,214 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C17H18Br2FN3O3S/c1-26-16-3-2-12(10-15(16)23-6-4-21-5-7-23)27(24,25)22-14-9-11(18)8-13(20)17(14)19/h2-3,8-10,21-22H,4-7H2,1H3 ; Key: BLWHAZZXRHTFJE-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

SB-357,134 je lek koji se koristi u naučnim istraživanjima. On deluje kao potentan, selektivan i oralno aktivan antagonist 5-HT₆ receptora.^[4] SB-357,134 i drugi 5-HT₆ antagonisti manifestuju nootropne efekte u životinjskim studijama,^[5]^[6]^[7] i potencijalno mogu da služe kao treatmen za kognitivne poremećaje kao što su šizofrenija i Alchajmerova bolest.

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Bromidge, SM; Clarke, SE; Gager, T; Griffith, K; Jeffrey, P; Jennings, AJ; Joiner, GF; King, FD i dr.. (2001). „Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)”. Bioorganic & Medicinal Chemistry Letters 11 (1): 55–8. DOI:10.1016/S0960-894X(00)00597-7. PMID 11140733.
↑ Rogers, DC; Hagan, JJ (2001). „5-HT6 receptor antagonists enhance retention of a water maze task in the rat”. Psychopharmacology 158 (2): 114–9. DOI:10.1007/s002130100840. PMID 11702084.
↑ Stean, TO; Hirst, WD; Thomas, DR; Price, GW; Rogers, D; Riley, G; Bromidge, SM; Serafinowska, HT i dr.. (2002). „Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist”. Pharmacology, Biochemistry, and Behavior 71 (4): 645–54. DOI:10.1016/S0091-3057(01)00742-0. PMID 11888556.
↑ Perez-García, G; Meneses, A (2005). „Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task”. Pharmacology, Biochemistry, and Behavior 81 (3): 673–82. DOI:10.1016/j.pbb.2005.05.005. PMID 15964617.

Vanjske veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[4] Bromidge, SM; Clarke, SE; Gager, T; Griffith, K; Jeffrey, P; Jennings, AJ; Joiner, GF; King, FD i dr.. (2001). „Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134)”. Bioorganic & Medicinal Chemistry Letters 11 (1): 55–8. DOI:10.1016/S0960-894X(00)00597-7. PMID 11140733.

[5] Rogers, DC; Hagan, JJ (2001). „5-HT6 receptor antagonists enhance retention of a water maze task in the rat”. Psychopharmacology 158 (2): 114–9. DOI:10.1007/s002130100840. PMID 11702084.

[6] Stean, TO; Hirst, WD; Thomas, DR; Price, GW; Rogers, D; Riley, G; Bromidge, SM; Serafinowska, HT i dr.. (2002). „Pharmacological profile of SB-357134: a potent, selective, brain penetrant, and orally active 5-HT(6) receptor antagonist”. Pharmacology, Biochemistry, and Behavior 71 (4): 645–54. DOI:10.1016/S0091-3057(01)00742-0. PMID 11888556.

[7] Perez-García, G; Meneses, A (2005). „Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task”. Pharmacology, Biochemistry, and Behavior 81 (3): 673–82. DOI:10.1016/j.pbb.2005.05.005. PMID 15964617.

[1]

[2]

[3]

[4]

[5]

[6]

[7]