BRL-44408

BRL-44408
(IUPAC) ime
	2-[(4,5-Dihidro-1H-imidazol-2-il)metil]-2,3-dihidro-1-metil-1H-izoindol
Klinički podaci
Identifikatori
CAS broj	118343-19-4
ATC kod	nije dodeljen
PubChem	121850
ChemSpider	108707
ChEMBL	CHEMBL216097
Hemijski podaci
Formula	C13H17N3
Mol. masa	215,293 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C13H17N3/c1-10-12-5-3-2-4-11(12)8-16(10)9-13-14-6-7-15-13/h2-5,10H,6-9H2,1H3,(H,14,15) ; Key: SGOFAUSEYBZKDQ-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

BRL-44408 je lek koji se koristi u naučnim istraživanjima. On deluje kao selektivni antagonist α_2A adrenoreceptora.^[5] Smatra se da može da ima potencijalnu terapeutsku primenu u tretmanu ekstrapiramidalnih nuspojava proizvedenih upotrebom pojedinih antipsihotičkih lekova.^[6]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Alberts P (January 1993). „Subtype classification of presynaptic alpha 2-adrenoceptors”. General Pharmacology 24 (1): 1–8. PMID 8387042.
↑ Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). „Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders”. Neuroscience Letters 454 (2): 143–7. DOI:10.1016/j.neulet.2009.03.001. PMID 19429072.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid8387042-5] Alberts P (January 1993). „Subtype classification of presynaptic alpha 2-adrenoceptors”. General Pharmacology 24 (1): 1–8. PMID 8387042.

[pmid19429072-6] Imaki J, Mae Y, Shimizu S, Ohno Y (April 2009). „Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders”. Neuroscience Letters 454 (2): 143–7. DOI:10.1016/j.neulet.2009.03.001. PMID 19429072.

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