Romifidin

Romifidin
IUPAC ime
	N-(2-bromo-6-fluorofenil)-4,5-dihidro-1H-imidazol-2-amin
Klinički podaci
Drugs.com	Internacionalno ime leka
Način primene	IV
Pravni status
Pravni status	Veterinarska upotreba;
Identifikatori
CAS broj	65896-16-4
ATCvet kod	QN05CM93 (WHO)
PubChem	CID 71969
UNII	876351L05K
Hemijski podaci
Formula	C9H9BrFN3
Molarna masa	258,09
	SMILES C1CN=C(N1)NC2=C(C=CC=C2Br)F; ;

Romifidin je lek koji se koristi u veterini kao sedativ uglavnom za velike životinje kao što su konji,^[1] mada se on može koristiti u širokom nizu vrsta.^[2]^[3] On se ne koristi za ljude, ali je blisko strukturno srodan sa lekom u širokoj upotrebi klonidinom.

Romifidin deluje kao agonist na α₂ adrenergičkom receptoru. Nuspojave mogu da obuhavataju bradikardiju i respiratornu depresiju. On se često koristi uporedo sa drugim sedativima ili analgeticima kao što je ketamin ili butorfanol.^[4]^[5] Johimbin se može koristiti kao antidot za brzo poništanje njegovog dejstva.

Reference

^ Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Spadavecchia, C.; Arendt-Nielsen, L.; Andersen, O. K.; Spadavecchia, L.; Schatzmann, U. (новембар 2005). „Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses”. American Journal of Veterinary Research. 66 (11): 1992—8. PMID 16334961. doi:10.2460/ajvr.2005.66.1992.
^ De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine. De Lucas, J. J.; Rodríguez, C.; Marín, M.; González, F.; Ballesteros, C.; San Andrés, M. I. (фебруар 2007). „Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine”. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine. 54 (1): 48—50. PMID 17359455. doi:10.1111/j.1439-0442.2007.00910.x.
^ Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Belda, E.; Laredo, F. G.; Escobar, M.; Soler, M.; Lucas, X.; Agut, A. (2008 Jan 19). „Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats”. Veterinary Record. 162 (3): 82—7. PMID 18204032. doi:10.1136/vr.162.3.82. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Corletto F, Raisis AA, Brearley JC. Corletto, F.; Raisis, A. A.; Brearley, J. C. (јануар 2005). „Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies”. Veterinary Anaesthesia and Analgesia. 32 (1): 16—22. PMID 15663735. doi:10.1111/j.1467-2995.2004.00184.x.
^ Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. Kerr, C. L.; McDonell, W. N.; Young, S. S. (октобар 2004). „Cardiopulmonary effects of romifidine/Ketamine or xylazine/Ketamine when used for short duration anesthesia in the horse”. Canadian Journal of Veterinary Research. 68 (4): 274—82. PMC 1111358 . PMID 15581222.

Spoljašnje veze

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Spadavecchia, C.; Arendt-Nielsen, L.; Andersen, O. K.; Spadavecchia, L.; Schatzmann, U. (новембар 2005). „Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses”. American Journal of Veterinary Research. 66 (11): 1992—8. PMID 16334961. doi:10.2460/ajvr.2005.66.1992.

[2] De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine. De Lucas, J. J.; Rodríguez, C.; Marín, M.; González, F.; Ballesteros, C.; San Andrés, M. I. (фебруар 2007). „Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine”. Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine. 54 (1): 48—50. PMID 17359455. doi:10.1111/j.1439-0442.2007.00910.x.

[3] Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Belda, E.; Laredo, F. G.; Escobar, M.; Soler, M.; Lucas, X.; Agut, A. (2008 Jan 19). „Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats”. Veterinary Record. 162 (3): 82—7. PMID 18204032. doi:10.1136/vr.162.3.82. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Corletto F, Raisis AA, Brearley JC. Corletto, F.; Raisis, A. A.; Brearley, J. C. (јануар 2005). „Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies”. Veterinary Anaesthesia and Analgesia. 32 (1): 16—22. PMID 15663735. doi:10.1111/j.1467-2995.2004.00184.x.

[5] Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. Kerr, C. L.; McDonell, W. N.; Young, S. S. (октобар 2004). „Cardiopulmonary effects of romifidine/Ketamine or xylazine/Ketamine when used for short duration anesthesia in the horse”. Canadian Journal of Veterinary Research. 68 (4): 274—82. PMC 1111358 . PMID 15581222.

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