Aglepristone

Aglepristone

Clinical data
Trade names	Alizin
Other names	RU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
Drug class	Antiprogestogen; Antiglucocorticoid
ATC code	G03XB90 (WHO)
Identifiers
IUPAC name (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
CAS Number	124478-60-0
PubChem CID	14153279
ChemSpider	16736563
UNII	0UT4JLE1CM
KEGG	D07096
ChEMBL	ChEMBL2103998
CompTox Dashboard (EPA)	DTXSID001016632
ECHA InfoCard	100.211.372
Chemical and physical data
Formula	C29H37NO2
Molar mass	431.620 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O
InChI InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1 Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N

Aglepristone (INNTooltip International Nonproprietary Name) (brand name Alizin; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone.^[1][2][3] Aglepristone, similarly to mifepristone, also possesses some antiglucocorticoid activity.^[4][5] Aglepristone is used as an abortifacent, to induce parturition, and as a treatment for mammary hyperplasia and pyometra. It is only used in cats and dogs.^[6]

See also

• Lilopristone
• Onapristone
• Telapristone
• Toripristone

References

1. Kaufman LK, Baldwin CJ (1 December 2013). "Pregnancy Loss in the Bitch and Queen". In Bonagura JD, Twedt DC (eds.). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. pp. 3009–. ISBN 978-0-323-22762-9.
2. Squires EJ (2010). "Endocrine manipulation of reproduction.". Applied Animal Endocrinology. CABI. pp. 207–. ISBN 978-1-84593-755-3.
3. Papich MC (3 November 2010). "Aglepristone". Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. pp. 120–. ISBN 978-1-4377-0192-0.
4. Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat". Reproduction in Domestic Animals = Zuchthygiene. 46 (5): 882–888. doi:10.1111/j.1439-0531.2011.01759.x. PMID 21320179.
5. Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs". Theriogenology. 69 (4): 399–407. doi:10.1016/j.theriogenology.2007.10.008. PMID 18054071.
6. Papich, Mark (2016). Saunders Handbook of Veterinary Drugs (4th ed.). Elsevier. ISBN 978-0-323-24485-5.