Karoksazon

Karoksazon
IUPAC ime
	2-(2-okso-4H-1,3-benzoksazin-3-il)acetamid
Klinički podaci
Kategorija trudnoće	?;
Način primene	Oralno
Pravni status
Pravni status	℞ (Prescription only);
Identifikatori
CAS broj	18464-39-6
ATC kod	none
PubChem	CID 29083
ChemSpider	27057
UNII	807N226MNL
Hemijski podaci
Formula	C10H10N2O3
Molarna masa	206,20 g/mol
	SMILES O=C(N)CN2C(=O)Oc1ccccc1C2; ;

Karoksazon (Surodil, Timostenil) je antidepresiv koji se nekad koristio za tretman depresije ali više nije u prodaji.^[1]^[2] On deluje kao reverzibilni inhibitor monoaminske oksidaze (MAOI) oba podtipa: MAO-A i MAO-B, sa pet puta većom potentnošću na MAO-B.^[3]^[4]^[5]^[6]^[7]

Reference

^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
^ Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). „A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline”. The Journal of International Medical Research. 6 (5): 388—94. PMID 359383.
^ Lieberman, A. N. (1994). Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. ISBN 0-8247-9082-0.
^ Moretti A; Caccia C; Martini A; et al. (1981). „Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers”. British Journal of Clinical Pharmacology. 11 (5): 511—5. PMC 1401585 . PMID 7272163.
^ Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (1981). „Studies on the mechanism of action of caroxazone, a new antidepressant drug”. Biochemical Pharmacology. 30 (19): 2728—31. PMID 6170295. doi:10.1016/0006-2952(81)90549-9.
^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man”. British Journal of Clinical Pharmacology. 11 (6): 611—5. PMC 1402186 . PMID 7272178.
^ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (1981). „Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man”. British Journal of Clinical Pharmacology. 11 (6): 605—10. PMC 1402193 . PMID 7272177.