Butanserin

Butanserin

Clinical data
Other names	R-53393; R53393; R-53,393
Drug class	Serotonin 5-HT2A receptor antagonist; α1-Adrenergic receptor antagonist; Antihypertensive agent
ATC code	None
Identifiers
IUPAC name 3-[4-[4-(4-fluorobenzoyl)piperidin-1-yl]butyl]-1H-quinazoline-2,4-dione
CAS Number	87051-46-5
PubChem CID	65652
DrugBank	DB19943
ChemSpider	59089
UNII	4I933V848G
ChEMBL	ChEMBL1742433
CompTox Dashboard (EPA)	DTXSID40236109
Chemical and physical data
Formula	C24H26FN3O3
Molar mass	423.488 g·mol^−1
3D model (JSmol)	Interactive image
SMILES C1CN(CCC1C(=O)C2=CC=C(C=C2)F)CCCCN3C(=O)C4=CC=CC=C4NC3=O
InChI InChI=1S/C24H26FN3O3/c25-19-9-7-17(8-10-19)22(29)18-11-15-27(16-12-18)13-3-4-14-28-23(30)20-5-1-2-6-21(20)26-24(28)31/h1-2,5-10,18H,3-4,11-16H2,(H,26,31) Key:MLDQSYUQSLUEPG-UHFFFAOYSA-N

Butanserin (INNTooltip International Nonproprietary Name; developmental code name R-53393) is a serotonin 5-HT₂ receptor antagonist and α₁-adrenergic receptor antagonist which was studied as an antihypertensive agent but was never marketed.^[1][2][3] It was first described in the scientific literature by 1984.^[1][2][3]

See also

• Serotonin 5-HT_2A receptor antagonist
• α₁-Adrenergic receptor antagonist

References

1. Elks, J. (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ISBN 978-1-4757-2085-3. Retrieved 16 January 2026.
2. Megens AA, Niemegeers CJ (August 1984). "Antagonism of the antidiarrhoeal effect of clonidine and the lethal effect of noradrenaline in rats: a reliable procedure to evaluate the in-vivo alpha 1- and alpha 2-blocking activity of drugs?". J Pharm Pharmacol. 36 (8): 516–520. doi:10.1111/j.2042-7158.1984.tb04442.x. PMID 6148393.
3. Korstanje C, Sprenkels R, Doods HN, Hugtenburg JG, Boddeke E, Batink HD, Thoolen MJ, Van Zwieten PA (May 1986). "Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin". J Pharm Pharmacol. 38 (5): 374–379. doi:10.1111/j.2042-7158.1986.tb04590.x. PMID 2872314.